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BCG for bladder cancer immunotherapy. The use of microbes in cancer immunotherapy was pursued long before 1976 when Morales and others established the salutary effects of intravesical BCG on human NMIBC patients [9-11].Now 45 years later, BCG remains the only bacterial agent approved by the FDA for cancer and remains the gold-standard treatment for patients with intermediate- and high-risk ...Abstract. Bacillus Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis that has been effectively used in the treatment of non-muscle invasive bladder carcinoma. The complications of this treatment are uncommon, and the causes of dissemination are still discussed. We report a case of disseminated tuberculosis in a 66-year-old ...

BCG vaccine. Bacillus Calmette-Guérin ( BCG) vaccine is a vaccine primarily used against tuberculosis (TB). [8] It is named after its inventors Albert Calmette and Camille Guérin. [9] [10] In countries where tuberculosis or leprosy is common, one dose is recommended in healthy babies as soon after birth as possible. [8]Learn about BCG’s local business consulting services, read thought leadership articles across industries, and connect with our leadership team in Germany.BCG induced macrophage activation also has significant impact on the anti-mycobacterial immune response and studies in mice have shown that mycobacterial killing by macrophages can be observed as early as 7 days post-BCG vaccination, suggesting that a portion of macrophage effector functions may be independent of adaptive immunity . Vaccinated ...

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